Forever 21 will close its flagship Scottish store, at the loss of around 200 jobs.
The retailer, one of the biggest in the US, has been in Scotland for under three years and the move comes amid a round of closures and downsizing from the Los Angeles-based business.
Forever 21 has already closed its Manchester store and, according to the Glasgow Evening Times, is expected to withdraw from a number of other UK locations.
Meanwhile, rival fast fashion chain H&M will takeover the unit.
In the US, Forever 21 accounts for 10% of the country's clothing market.